D301 :: DoE for BioProcess Optimisation :: 3 day
Run by UCL, in partnership with, and co-presented by, PRISMTC. This module shows practitioners how experimental design techniques can be used to rapidly understand and optimise bioprocess performance. It provides managers with methods to ensure the whole bioprocess sequence is operating robustly and development budgets are used effectively. Training is focused on the hands on use of DoE software rather than underlying statistics.
Topics Covered
Bioprocess case studies, supported by a series of introductory and expert lectures will enable you to:
- Generate appropriate experimental designs within fixed research budgets and timescales
- Ensure analytical methods can be validated and provide reliable data for process evaluation
- Rapidly screen and optimise different fermentation media and operating conditions
- Obtain the highest yield of active product throughout your downstream process sequence
Monday :
- Introduction to Module and Design of Experiments
- Introduction to Experimental Design Techniques and Software
- Case Studies: Analytical Method Validation (OFAT vs DoE)
- Industrial Analytical Method Validation using DoE
Tuesday :
- Screening and Optimisation of Microbial Fermentations
- Case Study: Fermentation Process Screening
- Case Study: Fermentation Process Optimisation and Scale-Up
- Application of DoE in Mammalian Cell Culture Process Development
Wednesday :
- Case Study: Primary Product Recovery by Microfiltration
- Optimisation and Validation of Chromatographic Steps for Antibody Purification
- Protein Refolding, Stabilisation and Formulation
- Bioprocess Management and Quality Benefits of DoE
- Discussion Forum
A social networking event will be held for delegates and speakers
When and Where? reserve a place (via UCL site)
- 12-14 May 2012 :: London, UK
