Design of Experiments training

DoE for Bioprocess Optimisation
D301 - 3 days

Run by UCL in partnership with, and co-presented by, Prism.

This module shows practitioners how experimental design techniques can be used to rapidly understand and optimise bioprocess performance. It provides managers with methods to ensure the whole bioprocess sequence is operating robustly and development budgets are used effectively. Training is focused on the hands on use of DoE software rather than underlying statistics.

Topics covered

Bioprocess case studies, supported by a series of introductory and expert lectures will enable you to:
  • Generate appropriate experimental designs within fixed research budgets and timescales
  • Ensure analytical methods can be validated and provide reliable data for process evaluation
  • Rapidly screen and optimise different fermentation media and operating conditions
  • Obtain the highest yield of active product throughout your downstream process sequence
Day 1 :
  • Introduction to Module and Design of Experiments
  • Introduction to Experimental Design Techniques and Software
  • Case Studies: Analytical Method Validation (OFAT vs DoE)
  • Industrial Analytical Method Validation using DoE
Day 2 :
  • Screening and Optimisation of Microbial Fermentations
  • Case Study: Fermentation Process Screening
  • Case Study: Fermentation Process Optimisation and Scale-Up
  • Application of DoE in Mammalian Cell Culture Process Development
Day 3 :
  • Case Study: Primary Product Recovery by Microfiltration
  • Optimisation and Validation of Chromatographic Steps for Antibody Purification
  • Protein Refolding, Stabilisation and Formulation
  • Bioprocess Management and Quality Benefits of DoE
  • Discussion Forum
  • A social networking event will be held for delegates and speakers

Software Tools Used

We regularly run this course using the following software packages, but please just contact us if you'd like to discuss using your current in-house tool instead:

We also use our own simulation tool, ProSim, in this workshop.

Who should attend?

  • New & improving DoE Practitioners.
  • Those wishing to understand how to DoE relates to Bioprocess applications.

Recommended Preparation

Some familiarity with DoE essential.

For further details of the current programme, please contact us or mbi-training@ucl.ac.uk.

Upcoming public deliveries of this workshop...

To view our full public training programme, please click here.


Date Workshop Software Venue Price
All prices exclude VAT. For full day workshops, the fee includes tea/coffee, lunch and a pdf copy of the workshop notes. Payment is required to secure reservation. Substitution of delegate names is allowed.

Note: public deliveries of this workshop are offered in collaboration with an external partner, so our partner's prices, discounts, cancellation policy and other T&Cs will be applied instead of our own. Please contact us for more information.